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KMID : 1123920020160010111
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Korean Journal of Oriental Physiology and Pathology
2002 Volume.16 No. 1 p.111 ~ p.116
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Experimental Studies on the Inhibitory Effect of Immediate-Type Allergic Reaction of Tongku-tang
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Kim Young-Bok
Yun Young-Gab
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Abstract
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This report describes an inhibitory effect of Tongku-tang(TKT) on mast cell-mediated immediate-type allergic reactions. TKT is an Oriental herbal prescription, which has been successfully applied for the treatment of allergic disorders, mainly skin anaphylactic diseases in eastern medicine. TKT has concentration-dependently inhibited the ear swelling response induced by intradermal injection of non-specific mast cell degranulator compound 48/80 in mice. TKT also inhibited mast cell-dependent passive cutaneous anaphylaxis activated by dinitrophenyl (DNP)-IgE antibody in rats. I studied the effect of TKT on the histamine and β-hexosaminase release from the rat peritoneal mast cells by compound 48/80. TKT did not inhibit significantly the histamine and β-hexosaminase release from the rat peritoneal mast cells by compound 48/80. However, TKT inhibited both TNF-α and IL-1β secretion induced by phorbol 12-myristate 13-acetate and A23187 respectively. These results provide evidence that TKT may be beneficial in the treatment of immediate-type allergic reaction.
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KEYWORD
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Tongku-tang(通竅湯), mast cell immediate-type allergic reactions, TNF-α and IL-1β
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